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desvenlafaxine will boost the degree or impact of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Desvenlafaxine inhibits CYP2D6; with better desvenlafaxine doses (ie, four hundred mg) lower the CYP2D6 substrate dose by approximately 50%; no dosage adjustment needed with desvenlafaxine doses seven consecutive days right